Effectiveness of ethanol extract of kirinyuh leaf (Chromolaena odorata L) on the increase the fibroblasts and angiogenesis in nose mucosa of rabbit (lepus curpaneums)

Wounds are the loss or damage to a part of body's tissue that disrupts tissue's continuity.Kirinyuh plants have been used as traditional wound treatment in various cultures worldwide. Purpose: To provethe effectiveness topical ethanol extract kirinyuh leaf ointment on increasing angiogenesis and fibroblasts inhealing rabbit nasal mucosal incisions. Methods: This research is an experimental study with posttest-only controlgroup design. The subjects consisted 25 rabbits divided into five groups; one positive control group, onenegative three groups. group was given betadine ointment, thenegative made by incision mucosa, groups were 5%,10%, 15% concentrations ointment. Results: results showed thatadministering 5%, 10%, could improve thehealing incisions (Lepus Curpaneums), which characterized increase thenumber angiogenesis. In general, fibroblast cells between theethanol significantly different (p0.05) negative correlation (r= -0.538).Meanwhile, there no significant difference amount witha relationship (r=0.099).Conclusion: applied topically improvesthe healing KEYWORDS: healing, fibroblast,